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Endocrine Abstracts

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ea0094oc4.4 | Reproductive Endocrinology | SFEBES2023

Intranasal kisspeptin: a novel, effective and non-invasive approach to stimulate reproductive hormones in patients with reproductive disorders

G Mills Edouard. , Delli Virginia , Chachlaki Konstantina , Silva Mauro SB. , Decoster Laurine , Ternier Gaetan , Thurston Layla , Phylactou Maria , Patel Bijal , Yang Lisa , Clarke Sophie A. , Alexander Emma , Choudhury Muhammad , Bech Paul , Abbara Ali , Swedrowska Magda , Forbes Ben , Giacobini Paolo , Prevot Vincent , Comninos Alexander N. , Dhillo Waljit S.

Background: Kisspeptin is a potent regulator of GnRH neurons with potential to treat reproductive and psychosexual disorders. However, administration is limited to the subcutaneous or intravenous routes. These invasive routes limit clinical development. Herein, we comprehensively examine the translational potential of intranasal kisspeptin administration for the first-time using rodent, human and pharmaceutical studies.Methods:</...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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